Table 3.

Baseline global cognitive scores as predictors of progression to algorithmically defined early cognitive impairment (ECI) during follow up.

Predictor	Time to event outcome	N†	Number of progressors	Person-years	Hazard ratio	95% CI
MMSE score *	clinical adjudication of MCI diagnosis	1503	44	18923	1.435	(0.486, 4.235)
	impairment in Card Rotation or CVLT immediate recall	965	370	9342	1.466	(0.981, 2.191)
	impairment in 1+ memory or 3+ non-memory tests	998	381	9741	1.704	(1.099, 2.642)
CDR-SB score *	clinical adjudication of MCI diagnosis	854	44	11665	1.929	(1.037, 3.590)
	impairment in Card Rotation or CVLT immediate recall	510	216	5097	1.928	(1.434, 2.593)
	impairment in 1+ memory or 3+ non-memory tests	530	226	5400	1.829	(1.362, 2.457)
BIMC score *	clinical adjudication of MCI diagnosis	1575	45	19392	1.424	(0.535, 3.790)
	impairment in Card Rotation or CVLT immediate recall	1003	378	9544	1.591	(1.113, 2.275)
	impairment in 1+ memory or 3+ non-memory tests	1039	392	9955	1.947	(1.348, 2.814)

Note. MCI=mild cognitive impairment. CVLT=California Verbal Learning Test. MMSE=Mini-Mental State Examination. CDR-SB=Clinical Dementia Rating - Sum of Boxes. BIMC=Blessed Information Memory Concentration test. CI=confidence interval.

^*Binary predictors were used in the Cox proportional hazards models, adjusted for age, sex, race, and years of education. Poor performance in global cognitive score was determined based on MMSE≤26, BIMC≥4, and CDR-SB≥0.5.

^†Participants who were impaired based on algorithmic definitions at baseline and who only had one visit were removed from the analyses.