KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Purified NA/LE Mouse Anti-Human CD3 (Clone UCHT1)	BD	Cat# 555329; RRID: AB_395736
Purified NA/LE Mouse Anti-Human CD28 (Clone CD28.2)	BD	Cat# 555725; RRID: AB_396068
HIV-1 core (p24) antigen-FITC (Clone KC57)	Beckman Coulter	Cat# 6604665; RRID: AB_1575987
Mouse anti-human CD4 Alexa Fluor 700 (Clone RPAT4)	BD	Cat# 557922; RRID: AB_396943
Mouse anti-human CD4 PerCP-Cy5.5 (Clone RPAT4)	BioLegend	Cat# 300530; RRID: AB_893328
Mouse anti-human CD3 Pacific Blue (Clone UCHT1)	BD	Cat# 558117; RRID: AB_397038
Mouse anti-human CCR6 PE (Clone 11A9)	BD	Cat# 559562; RRID: AB_397273
Mouse anti-human CCR5 PE (Clone 2D7/CCR5)	BD	Cat# 555993; RRID: AB_396279
Mouse anti human IFN-γ Alexa Fluor 700 (Clone B27)	BD	Cat# 557995; RRID: AB_396977
Mouse anti human CXCR4 APC (Clone 12G5)	Thermo Fisher	Cat# 17–9999–42; RRID: AB_1724113
Mouse anti human Ki67 BV421 (Clone B56)	BD	Cat# 562899; RRID: AB_2686897
Rat anti human Integrinβ7 PE-Cy 5 (Clone FIB504)	BD	Cat# 551059; RRID: AB_394026
Mouse anti human CD56 FITC (Clone HCD56)	eBioscience	Cat# 318304; RRID: AB_604100
Mouse anti human IL-17A PE (Clone eBio64DEC17)	eBioscience	Cat# 12–7179–42; RRID: AB_1724136
Mouse anti human IL-22 PE-Cyanine7 (Clone 22URTI)	eBioscience	Cat# 25–7229–42; RRID: AB_10853346
Mouse anti human CD8 FITC (Clone BW135/80)	Miltenyi Biotech	Cat# 130–080–601; RRID: AB_244336
Mouse anti human CD19 FITC (Clone LT19)	Miltenyi Biotech	Cat# 130–091–328; RRID: AB_244222
Mouse anti human CD45RA APCeFluor780 (Clone HI100)	eBioscience	Cat# 47–0458–42; RRID: AB_10853641
LIVE/DEAD Fixable Aqua Dead Cell Stain Kit (405 nm excitation)	Invitrogen	Cat# L34957
Rabbit anti human AhR	Abcam	Cat# ab190797; RRID: AB_2894707
Rabbit anti human AhR	Cell Signaling	Cat# 83200; RRID: AB_2800011
Rabbit anti human ARNT	Cell Signaling	Cat# 5537; RRID: AB_10694232
Normal Rabbit IgG	Cell Signaling	Cat# 2729; RRID: AB_1031062
Monoclonal anti-βActin (clone AC15)	Sigma	Cat# A5441; RRID: AB_476744
Bacterial and virus strains
HIV-1 THRO plasmid (pTHRO.c/2626), subtype B	NIH AIDS Reagent Program (Contribution of Dr. John Kappes and Dr. Christina Ochsenbauer)	Cat#11745
NL4.3BaL HIV plasmid	From Dr Roger J Pomerantz (Thomas Jefferson University, Philadelphia, Pennsylvania, USA) and Dr. Michel J. Tremblay (Université Laval, Québec City, QC, Canada)	N/A
Biological samples
Leukaphereses of ART treated and untreated people living with HIV	Recruited at the Montreal Chest Institute, McGill University Health Center and Center Hospitalier de l’Université de Montréal via the collaboration of Dr Jean-Pierre Routy’s group	N/A
Chemicals, peptides, and recombinant proteins
Dulbecco’s Modified Eagle’s medium (DMEM)	Thermo Fisher	Cat# 11995065
Roswell Park Memorial Institute (RPMI)	Thermo Fisher	Cat# 11875–093
Penicillin/Streptomycin	Gibco	Cat# 15140–122
Fetal Bovine Serum (FBS)	Sigma	Cat# F2442
Bovine Serum Albumin (BSA)	BioShop	Cat# ALB001
Phosphate Buffered Saline (PBS)	Thermo Fisher	Cat# 20012050
Tween 20	Thermo Fisher	Cat# BP337–500
PVDF membrane	Millipore Sigma	Cat# ISEQ00010
RIPA Buffer 10X	NEB	Cat# 9806S
rhIL-2	R&D Systems	Cat# 202–IL–050
rhIL-10	R&D Systems	Cat# 217–IL
rhIL-22	R&D Systems	Cat# 782–IL–010
CH-223191	Sigma	Cat# C8124
FICZ	Sigma	Cat# SML1489
DNAzol™ Reagent	Invitrogen	Cat# 10503027
T7 Endonuclease I - 250 units	NEB	Cat# M0302S
Phusion® High-Fidelity DNA Polymerase	NEB	Cat# M0530S
UltraComp ebeads	eBioscience	Cat# 01–2222–42
Formaldehyde 37%	Sigma	Cat#F79500
LC480 probe master mix	Roche	Cat# 4707494001
Amersham ECL Prime Western Blotting System	Cytiva	Cat# RPN2232
Brefeldin A	Sigma	Cat# B7651
PMA	Sigma	Cat# P1585
Ionomycin	Sigma	Cat# I0634
Luna Universal qPCR Master Mix	NEB	Cat# M3003E
TMB Peroxidase Substrate	Fitzgerald	Cat# 42R–TB102
Streptavidin Poly-HRP40	Fitzgerald	Cat# 65R–S104PHRP–200UG
Critical commercial assays
Memory CD4+ T cell Isolation Kit, human	Miltenyi	Cat#130–091–893
Fixation/Permeabilization Solution Kit (Cytofix/Cytoperm)	BD	Cat# 554714
Human IL-10 DuoSet ELISA	R&D Systems	Cat# DY217B
Human IL-17A (homodimer) ELISA Ready-SET-Go	Thermo Fisher	Cat# 88–7176–86
Human IL-22 DuoSet ELISA	R&D Systems	Cat# DY782
Human IFN-γ ELISA	Thermo Fisher	Cat# 88–7316–86
QuantiTect SYBR Green RT-PCR Kit	Qiagen	Cat# 204245
Human T cell Nucleofector® Kit	Lonza	Cat# VPA–1002
Rneasy Plus Mini Kit	Qiagen	Cat# 74136
CHIP assay kit	EMD Millipore	Cat# 17–295
Luna® Universal qPCR Master Mix	NEB	Cat# M3003S
MyTaq Extract PCR kit	Bioline	Cat# BIO–21126
High-fidelity enzyme Q5	NEB	Cat# M0530L
QIAEX II Gel extraction kit	Qiagen	Cat# 20021
GeneJET PCR Purification Kit	Thermo Fisher	Cat# K0702
Deposited data
RNA-Sequencing dataset	This paper	GEO: GSE198078
Original western blot images relative to Figures 1, S1 and S2.	This paper; Mendeley Data	https://data.mendeley.com/datasets/4ry9gxv7tp/1
Gene Ontology: Biological Processes database	Broad Institute	https://www.gsea-msigdb.org/gsea/msigdb/genesets.jsp?collection=BP
Homo Sapiens database GRCh 37 version75	Genome Reference Consortium	https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.13/
Experimental models: Cell lines
ACH-2 cell line	NIH HIV Reagent Program	Cat# ARP–349
293T cells	ATCC	Cat# CRL–3216
TZM-bl cells	NIH HIV Reagent Program	Cat# ARP–8129
HIV-p24 Abs producing hybridome	From Dr. Michel J. Tremblay (Université Laval, Québec City, QC, Canada)	N/A
Oligonucleotides
See Table S3: Oligonucleotides	This paper	N/A
Software and algorithms
Kallisto software version 0.44.0	Pachter Lab	https://pachterlab.github.io/kallisto/
FlowJo version 10	BD	https://www.flowjo.com/
GraphPad Prism 7	GraphPad	https://www.graphpad.com/
Microsoft Excel v16	Microsoft Office	https://www.microsoft.com/en-ca/microsoft-365/excel
Snapgene software	Snapgene	https://www.snapgene.com/
TIDE software	Tide	https://tide.nki.nl/
ICE software	Synthego	https://ice.synthego.com/
QuantStudio™ Design & Analysis Software	Thermo Fisher	https://www.thermofisher.com/