TABLE 2.
Activity of SIPI 1029 versus T. b. brucei in a standard model infectiona
| Dose (mg/kg/day) | MSD (days) | No. cured/no. total | % Cured |
|---|---|---|---|
| Control | 4.0 | 0/5 | 0 |
| 3-day dosing | |||
| 0.5 | 5/5 | 100 | |
| 1.0 | 5/5 | 100 | |
| 2.5 | 5/5 | 100 | |
| 5.0 | 5/5 | 100 | |
| 10.0 | 2.0 (T) | 4/5 | 80 |
| 1-day dosing | |||
| 0.5 | 9.8 | 1/5 | 20 |
| 1.0 | 8.7 | 2/5 | 40 |
| 2.5 | 12.5 | 3/5 | 60 |
| 5.0 | 3.0 | 4/5 | 80 |
| 10.0 | 5/5 | 100 |
a
Groups of five mice (20-g females) were infected with 2.5 × 105 trypanosomes, and the infections were allowed to develop for 24 h prior to treatment. SIPI 1029 was dissolved in distilled water and injected once daily (intraperitoneally) for 1 or 3 days. Animals surviving >30 days beyond the deaths of the untreated controls with no trypanosomes in tail vein blood smears were considered cured. MSD, mean survival in days exclusive of cured animals. (T), possible toxicity.