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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Adv Healthc Mater. 2023 May 25;12(26):e2300823. doi: 10.1002/adhm.202300823

Figure 4. Macrophage phenotypes were governed by spatial confinement in MAP scaffolds upon M1(LPS/IFNγ) activation.

Figure 4

a, Fold-change of inflammatory cytokine TNF and IL-6 secretion, and expression levels of pro-inflammatory markers iNOS and CD86, compared to the corresponding 2D culture with the same M1(LPS/IFNγ) activation. b, Expression levels of pro-regenerative markers CD206 and Arg1, compared to the corresponding 2D culture with the same M1(LPS/IFNγ) activation. c, Expression levels of antigen-presenting markers MHCII and CD11c compared to the corresponding 2D culture with the same M1(LPS/IFNγ) activation. e, Correlation matrix between phenotypical markers and selected morphological characteristics of BMDM encapsulated in MAP scaffolds upon M1(LPS/IFNγ) activation. Statistical analysis: one-way ANOVA with Tukey’s multiple comparisons test made between 40 μm, 70 μm and 130 μm MAP scaffolds groups only when there was significant difference among means. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Error bars, mean ± s.e.m., n = 3 from three independent experiments per scaffold type.