Figure 6:

Renal Ho-1 (A), Pgc1-α (B), and Gpx-4 (C) expression at 24-hours in mice exposed to hypoxia, normoxia, moderate hyperoxia, and severe hyperoxia during renal IR surgery. Effect of hyperoxia treatment determined by Jonckheere-Terpstra test for trend across normoxia, moderate hyperoxia, and severe hyperoxia groups. * indicates p <0.05 for comparison between animals administered hypoxia vs. normoxia, and # indicates p<0.05 for comparison of tempol vs. vehicle within each oxygen treatment, determined by Mann-Whitney U-Test.