Table 1 -.
Comparative analysis of differentially expressed genes with putative direct targets of SIX1.
| Stem Cell Development |
Neural Crest Cell Differentiation |
Ossification | Bone Development | ||||
|---|---|---|---|---|---|---|---|
| Up* | Down* | Up* | Down* | Up* | Down* | Up* | Down* |
| Dicer1 | Dicer1 | Rpl38 | Ddr2 | Has2 | Bnc2 | ||
| Ednra | Ednra | Fat4 | Tmem107 | Ddr2 | |||
| Frzb | Frzb | Fhl2 | Fat4 | ||||
| Fzd1 | Pax3 | Fzd1 | Igf1 | ||||
| Nrg1 | Rdh10 | Igf1 | Osr2 | ||||
| Pax3 | Rspo2 | Pdgfc | |||||
| Rdh10 | Satb2 | Thbs1 | |||||
| Tgfb2 | |||||||
| Chd3 | |||||||
| Cartilage Development |
Head Development | Ear Morphogenesis |
WNT Pathway | ||||
| Up* | Down* | Up* | Down* | Up* | Down* | Up* | Down* |
| Prrx2 | Dicer1 | Ddit4 | Dclk2 | Myc | Edrna | Cav1 | Ednra |
| Nfib | Dkk1 | Dicer1 | Prrx2 | Frzb | Dkk1 | Foxd1 | |
| Osr2 | Mgarp | Ednra | Rpl38 | Lrig1 | Frzb | ||
| Rspo2 | Tiparp | Egfr | Osr2 | Fzd1 | |||
| Satb2 | Fat4 | Sobp | Chd24 | ||||
| Tgfb2 | Nfib | Whrn | Fat1 | ||||
| Thbs1 | Nrg1 | Fat3 | |||||
| Osr2 | Pcdh9 | ||||||
| Pcdh19 | Pcdh19 | ||||||
| Ptch1 | Wnt7b | ||||||
| Rere | Tcf4 | ||||||
| Robo1 | |||||||
| Satb2 | |||||||
| Syne2 | |||||||
| Tgfb2 | |||||||
| Whrn | |||||||
*
Increased (Up) or decreased (Down) expression in Six1−/− (NULL) embryos relative to control (WT) embryos