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[Preprint]. 2023 Oct 9:2023.10.09.561507. [Version 1] doi: 10.1101/2023.10.09.561507

Figure 11.

Figure 11.

The product parallel pSTAT1 dimer and the substrate antiparallel uSTAT dimers of the activated TYK2/JAK1 heterodimeric complex. (A) Multiple closeup views of phosphorylation-dependent SH2 dimerization of the pSTAT1 dimer and details of binding pY residue into the pY-binding pocket of neighboring subunit as the means of docking of TYK2 pY onto the pY-binding pocket of SH2 in uSTAT. (B) Anti-parallel uSTAT1 dimer. (C) Conserved antiparallel uSTAT dimers of uSTAT1 (PDB ID 1yvl, grey), uSTAT5a (PDB ID 1y1u, green), and uSTAT3 (PDB ID 6tlc, gold) as a basis of docking onto the TYK2/JAK1 complex.