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[Preprint]. 2023 Oct 9:2023.10.09.561507. [Version 1] doi: 10.1101/2023.10.09.561507

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Figure 12. — Locations of pY on the modeled TYK2/IFNαR1-JAK1/IFNγR1 heterodimeric complex where IFNγR1 represents the biologically relevant IFNβR1 and docked antiparallel uSTAT1 on selected pY sites. (A) Front and back views of the modeled complex. TYK2 has 6 pY sites (292, 433, 604, 827, 1054 and 1055) and JAK1 has three pY sites (1033, 1034, and 1125). (B) Bottom-up view and a 45° rotated view of the docked antiparallel uSTAT1 dimers on pY292 and pY1055 of TYK2 and on pY1034 of JAK1. (C) A closeup of the pY292 site of TYK2. (D) The method for docking pY onto its binding pocket according to the parallel pSTAT1 crystal structure. (E) A closeup of the pY1034 site of JAK1. (F) A further closeup of the pY292 site of TYK2. See Video 6 for animation.