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[Preprint]. 2023 Oct 9:2023.10.09.561507. [Version 1] doi: 10.1101/2023.10.09.561507

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Figure 9. — Roles of ATP and TYK2-specific inhibitors during trans phosphorylation. (A, B) Stereodiagram of selected residues (A) and view of the full-surface representation of TYK2 JH1 (B) in the interface between TYK2 JH2 (cyan) and TYK2 JH1 (green) mediated by ATPγS. (C, D) The KZJ (or compound C)-inhibited complex of TYK2. (E, F) The DEU/Sotyktu-inhibited complex of TYK2. See Video 5 for animation.