Table 1.
key structural information references
| PDB ID | Brief description | Authors and citation |
|---|---|---|
| 1gag | IRTYK complex with bi-substrate analog | (Parang et al., 2001) |
| 4oli | TYK2 JH2-JH1 in the autoinhibited state | (Lupardus et al., 2014) |
| 5c03 | TYK2 JH2-ATPγS complex | (Min et al., 2015) |
| 6nzp | TYK2 JH2-Sotyktu complex | (Wrobleski et al., 2019) |
| 7t6f | The first active (JAK1/IFNλR1/ADP)2 complex | (Glassman et al., 2022) |
| 8ewy | The second active (JAK1/IFNλR1/ADP)2 complex | (Caveney et al., 2023) |
| 4po6 | Monomeric TYK2 FERM-SH2/IFNαR1 complex | (Wallweber et al., 2014) |
| 6nsl | TYK2 JH2-KZJ complex | (Liu et al., 2023) |
| 1bf5 | parallel dimer of the (pSTAT1)2-DNA complex | (Chen et al., 1998) |
| 1yvl | antiparallel dimer of the (uSTAT1)2 complex | (Mao et al., 2005) |
| 1y1u | antiparallel dimer of the (uSTAT5A)2 complex | (Neculai et al., 2005) |
| 6tlc | antiparallel dimer of the (uSTAT3)2 complex | (La Sala et al., 2020) |