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[Preprint]. 2023 Oct 12:2023.10.12.561972. [Version 1] doi: 10.1101/2023.10.12.561972

Figure 3. Arginine deprivation induces tolerance to multiple classes of antibiotics in S. aureus biofilms.

Figure 3.

Colony biofilms grown for 48 hours on polycarbonate filters on CDM agar plates were either transferred to fresh CDM or CDM-R plates with or without antibiotics (A, C, E, G), or were homogenized and transferred to liquid CDM or CDM-R media with or without antibiotics added (B, D, F, H). The following concentration of antibiotics were used: 400 μg/ml vancomycin (A,B), 20 μg/ml ceftaroline (C,D), 9 μg/ml delafloxacin (E,F), and 20 μg/ml linezolid (G,H). Data represent technical replicates of biological triplicates. 2-way ANOVA with Tukey multiple comparisons test; *=p<0.05, **=p<0.005, ***=p<0.0005, ****=p<0.0001, ns=not significant, ABX=antibiotics.