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[Preprint]. 2024 Jan 14:2023.09.30.560339. Originally published 2023 Oct 2. [Version 2] doi: 10.1101/2023.09.30.560339

Figure 2. Brain-wide reactivity through FOS counts and %-change: Alcohol withdrawal increases, naltrexone reduces whole-brain neuronal reactivity.

Figure 2.

(A) Total FOS counts between groups (*p=0.04, **p = 0.02 with one-way anova). (B) Regional FOS counts that are significantly different through 2 different approaches: q<0.1 False Discovery Rate on Dunnett test (*saline-treated alcohol dependent vs. non-dependent, #Nalterxone-treated dependent vs. saline-treated dependent; left). Bootstrapped 95-% confidence intervals (for *relative FOS %-change of naltrexone, R121919, and alcohol treatments vs. saline-treated control animals; middle or #naltrexone and R121919 treatments in dependent animals vs. saline-treated dependent animals; right). (C) Relative FOS %-change of naltrexone (x) and R121919 (y) treatments in dependent animals versus saline-treated dependent animals.