. 1998 Oct;42(10):2745–2746. doi: 10.1128/aac.42.10.2745

TABLE 2.

MICs of the acylated analogs of NPY for C. albicans

Peptide	MIC (μM)^a
Peptide	Unmodified	Acetylated^b	Succinylated^b
[Asn¹²]NPY(12–36)	1.0–1.5	3.0–3.5	14–16
[Thr¹²]NPY(12–36)	1.5	7.0–8.0	12–14
[Asp¹²]NPY(12–36)	3.0–4.0	20–25	40–60
[Lys¹²]NPY(12–36)	1.5	1.5–2.0	1.0–1.5

The MICs were determined from at least three independent experiments.

Acetylation and succinylation of the α-amino groups of the NPY analogs were performed before cleavage from the resin by the addition of acetic anhydride and succinic anhydride to the suspension of the resin-bound peptides, respectively.