Table 1.
Baseline characteristics of TrialNet PTP participants and DPT-1 participants included in the analysis. Numbers in the table are count (frequency) for categorical variables and median (IQR) for continuous variables.
| Variable | TrialNet PTP | DPT-1 |
|---|---|---|
|
| ||
| N | 954 (100⋅0%) | 706 (100⋅0%) |
| Sex | .. | .. |
| Female | 503 (52⋅9%) | 311 (44⋅1%) |
| Male | 448 (47⋅1%) | 395 (55⋅9%) |
| Ethnicity | .. | .. |
| Hispanic or Latino | 77 (8⋅3%) | 30 (4⋅2%) |
| Not Hispanic or Latino | 846 (91⋅7%) | 676 (95⋅8%) |
| Relatives with Type 1 Diabetes | .. | .. |
| Child | 151 (16⋅0%) | 184 (26⋅1%) |
| Parent | 183 (19⋅4%) | 31 (4⋅4%) |
| Sibling | 488 (51⋅8%) | 385 (54⋅5%) |
| Two or More FDR† | 48 (5⋅1%) | 47 (6⋅7%) |
| SDR* | 72 (7⋅6%) | 59 (8⋅4%) |
| BMI-z Score | 0⋅54 (−0⋅22,1⋅21) | 0⋅89 (0⋅24,1⋅54) |
| Age (Years) | 11 (7,21) | 11 (8,16) |
| Number of Positive Autoantibodies | 2 (1,3) | 3 (2,3) |
| GADA Titer (DK units/ml) | 282 (30,575) | 475 (39,695) |
| IA2A Titer (DK units/ml) | 1⋅6 (0⋅1,198⋅0) | 9 (0,262) |
| mIAA Titer (index) | 0⋅005 (0⋅001,0⋅022) | 0⋅001 (0⋅000,0⋅013) |
| ICA Titer (JDF units) | 0 (0,80) | 80 (40,320) |
| GADA Positivity | 716 (75⋅1%) | 518 (73⋅4%) |
| IA2A Positivity | 418 (43⋅8%) | 372 (52⋅7%) |
| mIAA Positivity | 360 (37⋅7%) | 174 (24⋅6%) |
| ICA Positivity | 444 (46⋅5%) | 703 (99⋅6%) |
| Glucose AUC (mg/dl) | 129 (115,148) | 128 (113,147) |
| Fasting Glucose (mg/dl) | 89 (84,95) | 86 (80,92) |
| C-peptide AUC (pmol/ml) | 4⋅9 (3⋅7,6⋅6) | 3⋅7 (2⋅7,4⋅7) |
| Fasting C-peptide (pmol/ml) | 1⋅4 (1⋅0,1⋅9) | 0⋅9 (0⋅6,1⋅3) |
| HbAlc (%) | 5⋅1 (4⋅9,5⋅3) | 5⋅3 (5⋅1,5⋅6) |
| Type 1 Diabetes GRS2 | 12⋅5 (11⋅0,13⋅8) | Not Available |
*
SDR: second-degree relative(s)
†
FDR: first-degree relative(s)