Table 1.
Evidence supporting the potential role of cPUFAs in brain disorders
| Triat1 | Trait2 | Genetic correlation | MR | Colocalization | A1 | A2 | β1 (SE1) | β2 (SE2) | P1 | P2 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rg | P | βIVW | P IVW | colocalized regions | PP | Candidate SNP | ||||||||
| Strong evidence | ||||||||||||||
| PUFA% | MDD | −0.193 | 7.14E-16 | −0.051 | 0.006 | chr21q22.3 | 0.829 | rs4818766 | G | A | −0.019 (0.004) | 0.022 (0.005) | 1.30E-06 | 6.38E-07 |
| PUFA% | AUDIT_C | 0.116 | 2.0E-3 | 0.014 | 0.019 | chr2p23.2 | 0.996 | rs 1260326 | C | T | 0.090 (0.004) | 0.007 (0.001) | 9.8E-113 | 5.47E-09 |
| Omega-6% | AUDIT_C | 0.084 | 0.036 | 0.019 | 0.001 | chr2p23.2 | 0.996 | rs 1260326 | C | T | 0.109 (0.004) | 0.007 (0.001) | 7.0E-159 | 5.47E-09 |
| PUFA% | AUDIT_T | 0.079 | 0.037 | 0.014 | 0.049 | chr2p23.2 | 0.999 | rs 1260326 | C | T | 0.090 (0.004) | 0.008 (0.001) | 9.8E-113 | 2.11E-10 |
| Suggestive evidence | ||||||||||||||
| LA% | ADHD | −0.338 | 3.25E-13 | −0.070 | 0.230 | chr9q21.32 | 0.768 | rs2576362 | T | G | 0.025 (0.005) | −0.067 (0.015) | 8.20E-08 | 1.30E-05 |
| PUFA% | ADHDa | −0.301 | 2.51E-12 | −0.089 | 0.151 | chr9q21.32 | 0.722 | rs6559744 | A | G | 0.025 (0.005) | −0.067 (0.015) | 1.90E-08 | 1.26E-05 |
| DHA% | AN | 0.276 | 6.35E-12 | 0.072 | 0.248 | chr6q16.1 | 0.797 | rs 1487445 | T | C | 0.020 (0.004) | 0.056 (0.013) | 4.30E-07 | 2.70E-05 |
| Omega-6% | ADHDa | −0.254 | 5.67E-08 | −0.062 | 0.306 | chr9q21.32 | 0.755 | rs 1982151 | G | A | −0.026 (0.005) | 0.068 (0.015) | 1.70E-08 | 1.04E-05 |
| PUFA% | SCZ | 0.100 | 2.0E-4 | 0.062 | 0.364 | chr12q24.31 | 0.858 | rs2851447 | C | G | −0.022 (0.005) | −0.091 (0.012) | 1.70E-06 | 2.19E-14 |
| chr1p36.11 | 0.854 | rs79598313 | T | C | −0.081 (0.013) | −0.141 (0.035) | 3.00E-09 | 4.86E-05 | ||||||
| Omega-3 % | SCZ | 0.091 | 0.006 | 0.013 | 0.815 | chr6p21.33 | 0.818 | rs2596500 | C | A | −0.027 (0.006) | −0.166 (0.018) | 1.10E-06 | 1.16E-19 |
| Omega-6% | SCZ | 0.077 | 0.006 | 0.015 | 0.779 | chr12q24.31 | 0.702 | rs2851447 | C | G | −0.024 (0.005) | −0.091 (0.012) | 2.30E-07 | 2.19E-14 |
| Omega-6: Omega-3 |
BIP | −0.068 | 0.042 | 0.041 | 0.429 | chr6p22.1 | 0.790 | rs3094067 | G | T | 0.029 (0.006) | −0.103 (0.016) | 7.20E-06 | 9.88E-11 |
| chr6p21.33 | 0.877 | rs3130490 | T | G | 0.028 (0.006) | −0.082 (0.016) | 3.30E-06 | 1.30E-07 | ||||||
Note: rg, genetic correlation; βIVW, estimated effects of trait 1 on trait 2 using IVW method; PP, posterior probability. A1, effect allele; A2, reference allele. β1, SE1 and β2, SE2 are genetic effects and standard errors of A1 on trait 1 and trait 2, respectively. P1 and P2 are P values for trait 1 and trait 2 extracted from GWAS summary statistics, respectively.
a
Th reverse MR of the two PUFA-ADHD pairs showed significant results (PIVW<0.05).