Table 3:
Association between insomnia and patient-centered outcomes
| Outcome Variable (MID) | Conceptual Domain measured | Parameter Estimate* Insomnia subscale MID = 12 | P-value |
|---|---|---|---|
|
VLA MID = 0.3 |
Physical functioning/disability | Per MID worsening: 0.05 (0.02, 0.09) | <0.01 |
| Worst quartile: 0.22 (0.06, 0.38) | 0.01 | ||
|
GDS MID = 1.65 |
Depression | Per MID worsening: 0.58 (0.25, 0.90) | <0.01 |
| Worst quartile: 2.33 (0.96, 3.70) | <0.01 | ||
|
Cognitive Limitations MID = 0.47 |
Cognitive impairments | Per MID worsening: 0.18 (0.11, 0.25) | <0.01 |
| Worst quartile: 0.71 (0.39, 1.03) | <0.01 | ||
|
SF36PCS MID = 5 |
Generic physical HRQL | Per MID worsening: −1.76 (−2.59, −0.93) | <0.01 |
| Worst quartile: −6.57 (−10.28, −2.86) | <0.01 | ||
|
SF36MCS MID = 5 |
Generic mental HRQL | Per MID worsening: −1.98 (−2.74, −1.22) | <0.01 |
| Worst quartile: −8.26 (−11.62, −4.90) | <0.01 | ||
|
AQ20R MID = 1.75 |
Respiratory-specific | Per MID worsening: 1.06 (0.67, 1.44) | <0.01 |
| Worst quartile: 4.47 (2.87, 6.07) | <0.01 | ||
|
EQ5D MID = 0.06 |
Health utility | Per MID worsening: −0.02 (−0.04, −0.01) | <0.01 |
| Worst quartile: −0.08 (−0.14, −0.02) | <0.01 | ||
|
SPPB MID = 1 |
Physical Frailty | Per MID worsening: −0.05 (−0.21, 0.11) | 0.54 |
| Worst quartile: 0.13 (−0.57, 0.82) | 0.72 | ||
|
FFP MID = 1 |
Physical Frailty | Per MID worsening: 0.12 (0.03, 0.21) | <0.01 |
| Worst quartile: 0.43 (0.03, 0.82) | 0.03 |
*
Adjusted for age, sex, transplant indication, and FEV1
MID = minimally important difference; LT-VLA = Lung Transplant Valued Life Activities scale; GDS = Geriatric Depression Scale; SF36PCS = Short Form 36 Physical Component Summary Scales; SF36MCS = Short Form 36 Mental Component Summary Scales; AQ20R = Airways Questionnaire 20-Revised; EQ5D = EuroQoL 5 Dimensions (5-level version); SPPB= Short Physical Performance Battery; FFP = Fried Frailty Phenotype.