Table 2.
Enriched KEGG Pathways Regulated by miRNAs Overexpressed or Underexpressed in ASC-Derived Exosomes
| Pathway | miRNAs | P |
|---|---|---|
| Overexpressed miRNA | ||
| Lysine degradation | hsa-miR-486-3p, hsa-miR-196a-5p, hsa-miR-1246, hsa-miR-193b-5p, hsa-miR-1290, hsa-miR-1306-5p | 3.11e-09 |
| Adherens junction | hsa-miR-196a-5p, hsa-miR-193b-5p, hsa-miR-486-3p, hsa-miR-1290, hsa-miR-1306-5p, hsa-miR-23a-5p | 1.19e-05 |
| TGF-β signaling pathway | hsa-miR-196a-5p, hsa-miR-23a-5p, hsa-miR-193b-5p, hsa-miR-1246, hsa-miR-1290, hsa-miR-1306-5p | 0.0020 |
| p53 signaling pathway | hsa-miR-196a-5p, hsa-miR-193b-5p, hsa-miR-486-3p, hsa-miR-1246, hsa-miR-1290, miR-1306-5p | 0.0151 |
| Hippo signaling pathway | hsa-miR-196a-5p, hsa-miR-193b-5p, hsa-miR-1246, hsa-miR-486-3p, hsa-miR-23a-5p, hsa-miR-1306-5p, hsa-miR-1290 | 0.0012 |
| FoxO signaling pathway | hsa-miR-196a-5p, hsa-miR-1246, hsa-miR-23a-5p, hsa-miR-486-3p, hsa-miR-193b-5p, hsa-miR-1306-5p, hsa-miR-1290 | 0.0015 |
| Regulation of actin cytoskeleton | hsa-miR-196a-5p, hsa-miR-1246, hsa-miR-1228-5p, hsa-miR-486-3p, hsa-miR-193b-5p, hsa-miR-1306-5p, hsa-miR-1290 | 0.0158 |
| Signaling pathways regulating pluripotency of stem cells | hsa-miR-196a-5p, hsa-miR-193b-5p, hsa-miR-1246, hsa-miR-1228-5p, hsa-miR-23a-5p, hsa-miR-1306-5p, hsa-miR-1290 | 0.0264 |
| Underexpressed miRNA | ||
| Lysine degradation | hsa-miR-34a-5p, hsa-miR-21-5p, hsa-miR-23b-3p, hsa-miR-23a-3p, hsa-miR-423-3p, hsa-miR-222-3p, hsa-miR-25-3p, hsa-miR-221-3p, hsa-miR-186-5p, hsa-miR-130a-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-24-3p, hsa-let-7a-5p, hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-let-7f-5p, hsa-let-7g-5p, hsa-miR-143-3p, hsa-miR-191-5p, hsa-miR-199a-3p, hsa-miR-199b-3p, hsa-let-7d-5p, hsa-let-7b-5p, hsa-miR-199a-5p | 8.14E-8 |
| Cell cycle | hsa-miR-25-3p, hsa-let-7f-5p hsa-let-7i-5p, hsa-let-7e-5p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-186-5p, hsa-miR-23b-3p hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-23a-3p, hsa-miR-222-3p, hsa-miR-221-3p, hsa-miR-34a-5p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-143-3p, hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-199a-3p, hsa-let-7b-5p, hsa-miR-21-5p, hsa-miR-24-3p, hsa-miR-199a-5p, hsa-let-7d-5p, hsa-let-7a-3p, hsa-miR-191-5p, hsa-miR-199b-3p | 7.17E-10 |
| Adherens junction | hsa-let-7f-5p, hsa-let-7i-5p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-23b-3p, hsa-miR-25-3p, hsa-miR-221-3p, hsa-let-7e-5p, hsa-miR-24-3p hsa-miR-130a-3p, hsa-miR-21-5p, hsa-miR-29a-3p, hsa-miR-186-5p, hsa-miR-34a-5p, hsa-miR-23a-3p, hsa-miR-143-3p, hsa-miR-199a-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-199a-5p, hsa-let-7b-5p, hsa-miR-191-5p, hsa-miR-199b-3p, hsa-miR-222-3p, hsa-miR-29b-3p, hsa-let-7d-5p, hsa-let-7a-3p, hsa-miR-423-3p | 1.33E-09 |
| Hippo signaling pathway | hsa-let-7e-5p, hsa-let-7a-5p, hsa-miR-34a-5p, hsa-miR-143-3p, hsa-let-7f-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-let-7i-5p, hsa-miR-23a-3p, hsa-let-7g-5p, hsa-miR-29b-3p, hsa-miR-21-5p, hsa-miR-29a-3p, hsa-miR-222-3p, hsa-miR-23b-3p hsa-miR-186-5p, hsa-miR-221-3p, hsa-miR-25-3p, hsa-miR-423-3p, hsa-miR-130a-3p, hsa-miR-199a-5p, hsa-miR-24-3p, hsa-let-7b-5p, hsa-miR-191-5p, hsa-miR-199a-3p, hsa-let-7d-5p, hsa-let-7a-3p, hsa-miR-199b-3p | 1.08E-07 |
| p53 signaling pathway | hsa-miR-130a-3p, hsa-miR-29b-3p, hsa-miR-143-3p, hsa-miR-21-5p, hsa-miR-23b-3p, hsa-miR-29a-3p, hsa-miR-221-3p, hsa-miR-34a-5p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-miR-125a-5p hsa-miR-125b-5p hsa-miR-222-3p, hsa-miR-25-3p, hsa-miR-186-5p, hsa-let-7f-5p, hsa-let-7i-5p, hsa-let-7a-5p hsa-let-7a-3p, hsa-let-7g-5p, hsa-miR-191-5p hsa-miR-199a-3p, hsa-miR-423-3p, hsa-let-7b-5p, hsa-miR-24-3p, hsa-let-7d-5p, hsa-miR-199b-3p, hsa-miR-199a-5p | 1.07E-06 |
| TGF-β signaling pathway | hsa-miR-222-3p, hsa-miR-21-5p, hsa-miR-23b-3p, hsa-miR-221-3p, hsa-let-7f-5p, hsa-miR-130a-3p, hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-34a-5p, hsa-miR-24-3p, hsa-let-7d-5p, hsa-let-7b-5p, hsa-let-7a-3p, hsa-miR-186-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-25-3p, hsa-miR-199a-5p, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-143-3p, hsa-miR-199a-3p, hsa-miR-199b-3p, hsa-miR-423-3p | 2.05E-07 |
| Regulation of actin cytoskeleton | hsa-miR-23b-3p, hsa-miR-21-5p, hsa-miR-29a-3p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-let-7a-5p, hsa-miR-29b-3p, hsa-miR-24-3p, hsa-miR-423-3p, hsa-let-7f-5p, hsa-miR-34a-5p, hsa-let-7i-5p, hsa-let-7g-5p, hsa-miR-25-3p, hsa-miR-130a-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-let-7a-3p, hsa-miR-199a-3p hsa-miR-199b-3p, hsa-miR-221-3p, hsa-miR-186-5p, hsa-miR-199a-5p, hsa-let-7b-5p, hsa-miR-191-5p, hsa-miR-222-3p, hsa-let-7d-5p, hsa-miR-143-3p | 0.0056 |
| Wnt signaling pathway | hsa-miR-23b-3p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-miR-186-5p, hsa-let-7f-5p, hsa-miR-34a-5p, hsa-let-7i-5p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-191-5p, hsa-miR-24-3p, hsa-miR-25-3p, hsa-miR-130a-3p, hsa-miR-29a-3p, hsa-let-7d-5p, hsa-let-7b-5p, hsa-miR-423-3p, hsa-miR-222-3p, hsa-miR-29b-3p, hsa-miR-21-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-let-7a-3p, hsa-miR-199a-3p, hsa-miR-221-3p, hsa-miR-199a-5p, hsa-miR-143-3p, hsa-miR-199b-3p | 0.0110 |
| FoxO signaling pathway | hsa-miR-25-3p, hsa-let-7f-5p, hsa-miR-199a-5p, hsa-miR-23b-3p, hsa-miR-130a-3p, hsa-miR-34a-5p, hsa-miR-23a-3p, hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-186-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-let-7i-5p, hsa-let-7e-5p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-let-7b-5p, hsa-miR-222-3p, hsa-miR-143-3p, hsa-miR-21-5p, hsa-miR-221-3p, hsa-let-7d-5p, hsa-miR-199a-3p, hsa-miR-423-3p, hsa-miR-24-3p, hsa-miR-199b-3p, hsa-let-7a-3p, hsa-miR-191-5p | 0.0001 |
| MAPK signaling pathway | hsa-miR-21-5p, hsa-miR-25-3p, hsa-let-7f-5p, hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-199a-5p, hsa-let-7a-5p, hsa-let-7a-3p, hsa-let-7g-5p, hsa-let-7d-5p, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-143-3p, hsa-miR-23b-3p, hsa-miR-34a-5p, hsa-miR-23a-3p, hsa-miR-199a-3p, hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-186-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-130a-3p, hsa-miR-191-5p, hsa-miR-423-3p, hsa-miR-222-3p, hsa-miR-221-3p, hsa-miR-199b-3p, | 0.0149 |
| DNA replication | hsa-miR-34a-5p, hsa-miR-24-3p, hsa-miR-130a-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-let-7f-5p, hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-25-3p, hsa-miR-143-3p, hsa-miR-186-5p, hsa-miR-21-5p, hsa-miR-23b-3p, hsa-let-7b-5p, hsa-let-7d-5p, hsa-miR-222-3p, hsa-miR-199a-3p, hsa-miR-199b-3p | 0.0353 |
| Apoptosis | hsa-miR-29b-3p, hsa-miR-29a-3p, hsa-miR-222-3p, hsa-miR-221-3p, hsa-let-7f-5p, hsa-let-7i-5p, hsa-let-7a-5p, hsa-let-7g-5p, hsa-miR-191-5p, hsa-miR-130a-3p, hsa-miR-23b-3p, hsa-miR-186-5p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-let-7b-5p, hsa-miR-21-5p, hsa-miR-199a-3p, hsa-miR-125a-5p, hsa-miR-34a-5p, hsa-miR-24-3p, hsa-miR-25-3p, hsa-let-7d-5p, hsa-miR-199b-3p, hsa-miR-199a-5p, hsa-miR-125b-5p, hsa-miR-423-3p, hsa-miR-143-3p | 0.0149 |