Table 2 ∣.
Selected humanized immunodeficient mouse models used in immuno-oncology
| Common name | Strain nomenclature | MGI IDa | Commercial source and repository number or refs. |
|---|---|---|---|
| General strains | |||
| B-NDG | NOD.Cg-Prkdcscid Il2rgtm1Bcgen/Bcgen | 7329796 | BCGEN:110586 |
| BRG | C;129S4-Rag2tm1.1Flv Il2rgtm1.1Flv/J | 4887943 | JAX:014593 |
| C57BL/6-RG | B6.Cg-Rag2tm1Fwa Il2rgtm1Wjl/Tac | 6438675 | TAC:4111 |
| CIEA BRG | C.Cg-Rag2tm1Fwa Il2rgtm1Sug/JicTac | 6438540 | TAC:11503 |
| CIEA NOG | NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac | 6438369 | TAC:NOG |
| NCG | NOD/ShiLtJGpt-Prkdcem26Gpt Il2rgem26Gpt/GptCrl | 6156913 | CRL:572 |
| NOG | NOD.Cg-Prkdcscid Il2rgtm1Sug/Jic | 5431525 | 9 |
| NPG | NOD.Cg-Prkdcscid Il2rgtm1Vst/Vst | 7329740 | BVB |
| NRG; NOD-RG | NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ | 3804477 | JAX:007799 |
| NSG | NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ | 3577020 | JAX:005557 |
| NSI | NOD.Cg-Prkdcscid Il2rgem1Pli/Pli | 7329032 | 244 |
| Strains with genetic modifications affecting MHC | |||
| DRAGA | NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)Dvs Tg(HLA-DRA,HLA-DRB1*0401)39-2Kito/J | 6478985 | JAX:035855 |
| HUMAMICE | STOCK Rag2tm1Fwa B2mtm1Unc Prf1tm1Sdz H2-Ab1tm1Doi Il2rgtm1Sug Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl | 6198377 | EMMA:06327 |
| NOG-dKO or NOG-B2Mnull, IAnull | NOD.Cg-B2mtm1Unc Prkdcscid H2-Ab1tm1Doi Il2rgtm1Sug/Jic | 7329748 | 78 |
| NOG I-Abeta <−/−> | NOD.Cg-Prkdcscid H2-Ab1tm1Doi Il2rgtm1Sug/Jic | 5431530 | 78 |
| NSG-A2/DR1 | NOD.Cg-Prkdcscid Mcph1Tg(HLA-A2.1)1Enge Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Alpl | 7330165 | 147 |
| NSG-B2Mnull IA IEnull | NOD.Cg-B2mtm1Unc Prkdcscid H2dlAb1-Ea Il2rgtm1Wjl/SzJ | 6271996 | JAX:030547 |
| NSG-(KbDb)nullIAnull | NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-Ab1em1Mvw H2-D1tm1Bpe Il2rgtm1Wjl/SzJ | 6197202 | JAX:025216 |
| Strains with genetic modifications for cytokine overexpression | |||
| BRGST | B6.Cg-Rag2tm1Fwa SirpaIdd13.2-NOD/ShiLt Il2rgtm1Wjl Tg(Krt14-Tslp)#Dfk/Pas | 7329944 | 133 |
| hIL2-NOG | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL2)4-2Jic/JicTac | 6438606 | TAC:13440 |
| MISTRG | C;129S4-Rag2tm1.1Flv Csf1tm1(CSF1)Flv Csf2/Il3tm1.1(CSF2,IL3)Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J | 5555040 | JAX:017712 |
| MISTRG6 | C;129S4-Rag2tm1.1Flv Csf1tm1(CSF1)Flv Csf2/Il3tm1.1(CSF2,IL3)Flv Thpotm1.1(TPO)Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J | NA | 217 |
| NOG-EXL | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(SV40/HTLV-IL3,CSF2)10-7Jic/JicTac | 6438862 | TAC:13395 |
| NSG-SGM3 | NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J | 5566536 | JAX:024099 |
| Strains with other genetic modifications | |||
| BRGS | B6.Cg-Rag2tm1Fwa SirpaIdd13.2-NOD/ShiLt Il2rgtm1Wjl/Kyu | 7329783 | 209,245 |
| BRGSKW-v | B6.Cg-Rag2tm1Fwa SirpaIdd13.2-NOD/ShiLt KitWv Il2rgtm1Wjl/Kyu | 7329802 | 115 |
| NBSGW | NOD.Cg-KitW41J Tyr+ Prkdcscid Il2rgtm1Wjl/ThomJ | 5613001 | JAX:026622 |
| NOG-pRorc γc | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(Rorc-Il2rg)#Takah/Takah | 7330081 | 132 |
| NSG-W41 | NOD.Cg-KitW-41J Prkdcscid Il2rgtm1Wjl/WaskJ | 5779915 | JAX:026497 |
| TKO | B6.129(Cg)-Rag2tm1Fwa Cd47tm1Fpl Il2rgtm1Cgn/KhasJ | 5528885 | 176 |
a
To retrieve records, enter ‘MGI:’ and the ID number (with no spaces in between) in the Quick Search box at http://www.informatics.jax.org. BCGEN, Byocytogen; BVB, Beijing Vitalstar Biotechnology; CRL, Charles River Laboratories; EMMA, European Mouse Mutant Archive; ID, identification; JAX, Jackson Laboratory; MGI, Mouse Genome Informatics; NA, not available; TAC; Taconic.