Figure 4. Most symptoms are strongly associated with female sex at birth and younger age.

The question asked was: “In the last 6 months, have you had any of the symptoms below often, repeatedly, or constantly? Please mark any that apply.” Sex-biased (X-axis) and/or Age-biased (Y-axis) associations in a logistic regression analysis ( Symptom ~ age + sex + intercept) are shown as data points. Data points within the blue-shaded areas are not significant after accounting for 82 tests ( p<0.05/82, or |Z|<3.427. Only one symptom (“Feeling easily annoyed or irritable”) was male-biased; 3 symptoms (sensitivities to chemicals or medicine, or bladder problems) were associated with older age. Results for 80 symptoms are shown.