Figure 2.

FH Variant Carrier Status and LDL-C metrics. (A) Density distributions of the first, maximum, and mean low-density lipoprotein cholesterol (LDL-C) measurements observed in the electronic health record (EHR) for individuals with and without familial hypercholesterolemia (FH) genetic variants. (B) Receiver operating characteristic curve for predicting FH variant carrier status using each LDL-C metric with adjustment for age at measurement. For Mean LDL-C, the age at each measurement was used to calculate a mean age across all measurements. To convert LDL-C values from mg/dL to mmol/L, divide by 38.67.