Figure 3.

Illustration of case-control sets with matched etiologic exposure windows. Incidence density sampling was used to generate matched sets for the nested case-control study. For each case, the index date was set to the date of the first CAD code. Any subject with no CAD codes before or within 1 month after the index date was eligible to serve as a control, and 10 random controls were selected, matching on the date of the first LDL-C measurement, the year of birth, sex, and ancestry. FH = familial hypercholesterolemia. CAD = coronary artery disease. LDL-C = low-density lipoprotein cholesterol.