Table 3.

Characteristic of the nested case-control cohort

Characteristic	CAD cases	Matched Controls
Demographics
n	23,091	230,910
Male	22,497 (97.4)	224,970 (97.4)
Age at enrollment (years)	66.3 ± 9.1	66.3 ± 9.0
Ancestry group
African	3,620 (15.7)	36,200 (15.7)
Asian	144 (0.6)	1,440 (0.6)
European	17,553 (76.0)	175,530 (76.0)
Hispanic	1,434 (6.2)	14,340 (6.2)
Unclassified	340 (1.5)	3,400 (1.5)
Lipid Data
Age at first LDL-C (years)	57.3 ± 9.0	57.2 ± 9.0
First LDL-C to index date (years)	5.7 ± 4.6	5.7 ± 4.5
LDL-C (mg/dL)
First	131.6 ± 42.5	125.2 ± 38.5
Maximum prior to index date	164.0 ± 54.8	151.0 ± 48.5
Mean prior to index date	130.7 ± 36.5	124.1 ± 32.9
Medical history
Hypertension
prior to first LDL-C	11,447 (49.6)	93,759 (40.6)
prior to index date	17,938 (77.7)	148,201 (64.2)
Diabetes
prior to first LDL-C	5,634 (24.4)	33,379 (14.5)
prior to index date	9,438 (40.9)	61,175 (26.5)
Tobacco
prior to first LDL-C	4,115 (17.8)	32,561 (14.1)
prior to index date	8,320 (36.0)	62,993 (27.3)
Statin use
prior to first LDL-C	3,882 (16.8)	29,076 (12.6)
prior to index date	14,644 (63.4)	113,023 (48.9)
FH variant carrier	103 (0.4)	651 (0.3)
Case type
Prevalent cases	17,642 (76.4)	NA
Index date to enrollment (years)	5.7 (4.1)	NA
Incident cases	5,449 (23.6)	NA
Enrollment to index date (years)	2.0 (1.5)	NA

Values are n (%) or mean ± SD. To convert LDL-C values from mg/dL to mmol/L, divide by 38.67.

CAD = coronary artery disease

LDL-C = low-density lipoprotein cholesterol

FH = familial hypercholesterolemia

NA = not applicable