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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Immunol. 2023 Nov 1;211(9):1332–1339. doi: 10.4049/jimmunol.2300156

FIGURE 2. Antibody variable heavy chain use dysregulated in pediatric NMDAR-AE.

FIGURE 2.

(A) Single B cells from the cerebrospinal fluid of a pediatric NMDAR-AE patient were queried for their antibody variable heavy chain usage and compared to the expected frequency in healthy controls. (B) Mutational frequencies within each variable antibody heavy chain family. (C) Replacement frequencies within each variable antibody heavy chain family. (D) CDR:FR ratio of replacement frequency within each variable antibody heavy chain family.