Table 3. Models for differentiating patients with semantic variant primary progressive aphasia patients from controls with NC and patients with AD.
| Variables | Volume-based modela | Texture-based modela | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fold 1 | Fold 2 | Fold 3 | Fold 4 | Fold 5 | Fold 1 | Fold 2 | Fold 3 | Fold 4 | Fold 5 | ||
| From NC | |||||||||||
| Intercept | −9.558 | −4.046 | −3.148 | −3.170 | −3.738 | −8.321 | −5.712 | −5.101 | −3.670 | −6.012 | |
| Left AMG | - | - | - | - | −2.421 | - | - | - | - | 1.691 | |
| Left FFG | - | - | - | - | - | - | - | - | - | - | |
| Left HPC | −2.095 | - | - | - | - | - | - | - | - | - | |
| Left PHG | - | - | - | - | - | - | 1.275 | 0.838 | 0.719 | - | |
| Left ERC | −3.578 | −1.460 | −1.466 | −1.381 | −1.359 | - | - | - | - | - | |
| Left TPC | - | −0.732 | - | - | - | - | 1.440 | - | - | - | |
| Left ITC | - | - | - | - | - | 3.342 | 1.609 | 2.794 | 2.072 | 2.404 | |
| Left MTC | −3.747 | −1.112 | −0.808 | −0.737 | - | - | - | - | - | - | |
| Left STC | - | - | - | - | - | - | - | - | - | 2.341 | |
| Right AMG | −1.774 | - | - | - | - | 2.350 | 1.515 | - | - | - | |
| Right FFG | - | - | −0.733 | −0.913 | - | - | - | - | - | - | |
| Right HPC | - | - | - | - | - | 2.709 | - | 1.167 | 0.876 | 1.430 | |
| Right PHG | - | - | - | - | −1.221 | - | - | - | - | - | |
| Right ERC | - | - | - | - | - | - | - | - | - | - | |
| Right TPC | - | - | - | - | - | - | - | - | - | - | |
| Right ITC | - | - | - | - | - | - | - | - | - | - | |
| Right MTC | - | - | - | - | - | - | - | - | - | - | |
| Right STC | - | - | - | - | - | - | - | - | - | - | |
| AUC | 0.819 | 0.861 | 0.986 | 0.944 | 0.861 | 0.750 | 0.889 | 0.931 | 1.000 | 1.000 | |
| From AD | |||||||||||
| Intercept | −1.747 | −2.810 | −1.609 | −1.346 | −0.269 | −1.945 | −2.142 | −2.083 | −2.128 | −1.538 | |
| Left AMG | - | - | - | - | - | - | - | - | - | - | |
| Left FFG | - | - | - | - | - | - | - | - | - | - | |
| Left HPC | - | - | - | 0.595 | - | - | - | - | - | - | |
| Left PHG | - | - | - | - | - | - | - | - | - | - | |
| Left ERC | - | - | - | - | - | 0.414 | 0.351 | 0.379 | 0.333 | - | |
| Left TPC | −0.754 | −0.968 | −0.695 | −0.723 | −0.627 | 0.592 | 0.741 | 0.398 | 0.481 | 0.421 | |
| Left ITC | - | - | - | - | - | - | - | - | - | - | |
| Left MTC | - | - | - | - | - | - | - | - | - | - | |
| Left STC | - | −0.757 | - | - | - | - | - | - | - | - | |
| Right AMG | - | - | - | −0.952 | - | - | - | - | - | - | |
| Right FFG | - | - | - | - | - | - | - | - | - | - | |
| Right HPC | - | - | - | 1.007 | 0.623 | - | - | - | - | - | |
| Right PHG | - | - | - | - | - | - | - | - | - | - | |
| Right ERC | - | - | - | - | - | −0.238 | −0.243 | - | - | - | |
| Right TPC | - | - | - | - | - | - | - | - | - | - | |
| Right ITC | - | - | - | - | - | - | - | - | - | - | |
| Right MTC | - | - | - | - | - | - | - | - | - | - | |
| Right STC | - | - | - | - | - | - | - | - | - | - | |
| AUC | 0.625 | 0.597 | 0.750 | 0.681 | 0.639 | 0.722 | 0.833 | 0.667 | 0.722 | 0.931 | |
NC = normal cognition, AD = Alzheimer’s disease, AMG = amygdala, FFG = fusiform gyrus, HPC = hippocampus, PHG = parahippocampal gyrus, ERC = entorhinal cortex, TPC = temporal polar cortex, ITC = inferior temporal cortex, MTC = middle temporal cortex, STC = superior temporal cortex, AUC = area under the receiver operating characteristic curve.
aForward selection in logistic regression analysis with five-fold cross-validation.