Figure 2.

Best-characterized forms of synaptic plasticity in hippocampal interneurons

(A) PC to IN synaptic LTP formation has been shown to be either CP-AMPAR dependent, e.g., in PV BCs (left) or NMDAR dependent, e.g., in NGFCs (right). Red dots represent glutamate release.

(B) IN to PC plasticity examples. Induction of presynaptic LTD in CCK BC to PC synapses (left): postsynaptic (PC) eCB signaling mediates the activation of presynaptic CB1Rs that in turn regulate the reduction of GABA release from the CCK-BC axonal terminals. T and L type VGCC-dependent LTP in SOM to PC synapses (right): coincident activation of both presynaptic SOM cell and postsynaptic PC cell leads to activation of T and L type VGCCs in PC dendrites that induces the activation of CaMKII. CaMKII activation leads in inhibitory LTP in SOM to PC synapses. Red dots represent GABA release. Figure created with BioRender and designed based on data from published work.^{123,124,125,126,127}