Table 2.

Risk of Bias Tool (RoB 2) Results by Domain

Study title	D1: randomization process	D2: deviations from intended intervention	D3: missing outcome data	D4: measurement of the outcome	D5: Selection of reported results	Overall rating
SEACAP	Low risk	Low risk	Low risk	Some concerns	Low risk	Low risk
IMPACT	Low risk	Low risk	Low risk	Some concerns	Low risk	Low risk
SUMMIT	Some concerns	Low risk	Low risk	Some concerns	Low risk	Some concerns
CAMEO	Some concerns	Low risk	Low risk	Some concerns	Low risk	Some concerns
CAMMPS	Low risk	Low risk	Some concerns	Some concerns	Low risk	Some concerns
TOPCARE	Some concerns	Low risk	Low risk	Low risk	Low risk	Some concerns
SCOPE	Low risk	Low risk	Low risk	Some concerns	Low risk	Some concerns
RELAX	High risk	Low risk	Low risk	Some concerns	Some concerns	High risk
CALM	Low risk	Low risk	Low risk	Some concerns	Low risk	Low risk
AHEAD	Low risk	Low risk	Low risk	Some concerns	Low risk	Low risk
DROP	Low risk	Low risk	Low risk	Some concerns	Low risk	Low risk