Fig. 4. Age-associated changes in titer of anti-nucleocapsid antibody and LLL-specific CD8⁺ T cells in uninfected and convalescent donors.

a Average anti-nucleocapsid IgG antibody titer was no obvious change with age in convalescent donors. For donors with multiple visits, the concentrations were averaged and depicted as a single point. The correlation between anti- nucleocapsid IgG antibody and age are shown by the pink trendline using the mixed effect linear regression model adjusted with sex. Error bounds indicating a 95% confidence interval (light gray) (n = 74). S = slope used in this figure. b Correlation between frequency of LLL-specific CD8⁺ T cells and donor’s age. For donors with multiple visits, the frequencies were averaged and depicted as a single point. Pink line represents convalescent donors and green line represent uninfected donors, and they were generated using the mixed effect linear regression model adjusted with sex. c Correlation between frequency of LLL-Tet⁺ CD8⁺ T_CM cells and donor’s age. For donors with multiple visits, the frequencies were averaged and depicted as a single point. Purple line represents convalescent donors and green line represent uninfected donors, and they were generated using the mixed effect linear regression model adjusted with sex. d Correlation between degree of LLL Tet⁺ CD8⁺ T cell expansion and donor’s age. For donors with multiple visits, the expansions were averaged and depicted as a single point. Purple line represents convalescent donors which was generated using the mixed effect linear regression model adjusted with sex.