Table 2.

Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with disease-free survival in patients with colorectal cancer.

Clinicopathological characteristics	Disease-free survival
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.356 (1.135–1.619)	0.001	1.508 (1.256—1.810)	< 0.001
T stage (T3–4)	2.034 (1.617–2.558)	< 0.001	1.481 (1.159—1.892)	0.002
N stage
N0	Ref
N1	1.798 (1.460–2.214)	< 0.001	1.586 (1.280—1.967)	< 0.001
N2	4.048 (3.250–5.042)	< 0.001	3.262 (2.568—4.143)	< 0.001
Perineural invasion (Positive)	1.678 (1.292–2.179)	< 0.001	0.993 (0.742—1.328)	0.960
Vascular invasion (Positive)	1.995 (1.619–2.457)	< 0.001	1.426 (1.124—1.809)	0.003
Macroscopic type
Protrude type	Ref
Infiltrating type	1.539 (1.091–2.170)	0.014	1.447 (1.024—2.045)	0.036
Ulcerative type	1.387 (1.119–1.719)	0.003	1.153 (0.925—1.437)	0.205
Differentiation (High-medium)	0.699 (0.548–0.893)	0.004	0.865 (0.673—1.112)	0.256
Tumor location (Colon cancer)	0.800 (0.670–0.956)	0.014	0.783 (0.653—0.939)	0.008
CIPI (High)	1.694 (1.420–2.021)	< 0.001	1.443 (1.203—1.730)	< 0.001

CRC colorectal cancer; BMI body mass index; CIPI cancer-inflammation prognostic index.