Table 3.

Univariate and multivariate Cox regression analysis of clinicopathological characteristics associated with overall survival in patients with colorectal cancer.

Clinicopathological characteristics	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.453 (1.206–1.749)	< 0.001	1.602 (1.323—1.939)	< 0.001
T stage (T3–4)	2.129 (1.668–2.717)	< 0.001	1.464 (1.129—1.900)	0.004
N stage
N0	Ref		Ref
N1	1.805 (1.452–2.244)	< 0.001	1.586 (1.266—1.987)	< 0.001
N2	4.144 (3.303–5.199)	< 0.001	3.416 (2.672—4.368)	< 0.001
Perineural invasion (Positive)	1.633 (1.244–2.143)	< 0.001	0.953 (0.703—1.292)	0.757
Vascular invasion (Positive)	2.024 (1.632–2.509)	< 0.001	1.415 (1.107—1.808)	0.006
Macroscopic type
Protrude type	Ref		Ref
Infiltrating type	1.535 (1.071–2.202)	0.02	1.468 (1.022—2.108)	0.038
Ulcerative type	1.406 (1.122–1.761)	0.003	1.171 (0.929—1.475)	0.181
Differentiation (High-medium)	0.643 (0.502–0.824)	< 0.001	0.800 (0.620—1.032)	0.086
Tumor size	1.218 (1.014–1.464)	0.035	1.073 (0.887—1.297)	0.468
CIPI (High)	1.780 (1.481–2.139)	< 0.001	1.442 (1.189—1.749)	< 0.001

CRC colorectal cancer; BMI body mass index; CIPI cancer-inflammation prognostic index.