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. 2023 Oct 23;14:6721. doi: 10.1038/s41467-023-42564-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a H&E staining of liver sections. 4x enlarged images are also shown. b The number of cells in 1 mm² from H&E-stained liver section. Smaller cell numbers in a unit area in OPA1-KO liver indicate larger size cells. n = 4 animals per group. Data are presented as mean values +/- SD. Unpaired t test. p = 0.0154. c Serum ALT measurements. n = 9 animals per group. Data are presented as mean values +/- SD. Unpaired t test. p < 0.0001. d Serum AST measurements. n = 6 animals per group. Data are presented as mean values +/- SD. Unpaired t test. P = 0.0005. e Serum LDH measurements. n = 6 animals per group. Data are presented as mean values +/- SD. Unpaired t test. f Immunoblots of floxed and OPA1-KO livers for markers of apoptosis and autophagy. g Quantification of (f). Significantly decreased caspase 3 cleavage and LC3-II/LC3-I ratio in OPA1-KO liver. n = 5 animals per group. Data are presented as mean values +/- SD. Unpaired t test. ****p < 0.0001; **p = 0.0011; *p = 0.0463. Source data are provided as a Source Data file.