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. 2023 Oct 23;14:6721. doi: 10.1038/s41467-023-42564-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a–c Mitochondrial swelling by light scattering assays. Swelling profiles of control (a) and OPA1-KO (b) mitochondria with and without CsA, and quantification (c). n = 4 animals per group. Data are presented as mean values +/- SD. Unpaired t test. ***p = 0.0001; ****p < 0.0001. d, e Mitochondrial Ca²⁺ uptake profiles with 50 μM (d) and 100 μM (e) CaCl₂ added to the mitochondrial suspension. The inset in (d) is the calculated Ca²⁺ uptake rate (nmol/min/mg mito). n = 4 animals per group. Data are presented as mean values +/- SD. Paired t test. **p = 0.0036. f–h Mitochondrial ROS production with glutamate/malate (f, GM) and succinate (g) as substrate, and quantification (h). n = 4 animals per group. Data are presented as mean values +/- SD. Paired t test. **p = 0.0017; ***p = 0.0001. i OPA1 KO increases the levels of MCU, NCLX, CypD, and MnSOD. j Quantification of (i). n = 5 animals per group. Data are presented as mean values +/- SD. Unpaired t test. ****p < 0.0001; *p = 0.0189; ***p = 0.0002. Source data are provided as a Source Data file.