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. 2023 Oct 23;14:6699. doi: 10.1038/s41467-023-42360-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a By analysis of the GSE25097 dataset¹⁰, we found upregulation of CDK6 mRNA in a cohort of human HCC samples (tumor n = 268 and adjacent non-tumor n = 243). In addition, CDK6 was upregulated in cirrhotic samples (n = 40) compared to healthy donors (n = 6) (two-tailed t test). b A tissue microarray consisting of 51 tumor tissues and corresponding non-tumor liver tissues was subjected to IHC analysis. Case 8 showed low expression of CDK6, while case 20 showed high expression of this protein. Scale bars = 50 µm and 200 µm. c Patients with high CDK6 expression (n = 21) had shorter disease-free survival than those with low expression (n = 21) (p = 0.0412; log-rank test). High-CDK6 expression was significantly correlated with HCC recurrence (p = 0.0078; χ² test). Data was presented as mean ± standard deviation. Source data are provided as a Source Data file.