Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 23;14:6699. doi: 10.1038/s41467-023-42360-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — a Schematic diagram of the treatment regimen of mock (0.5% methylcellulose in saline), palbociclib (100 mg/kg), lenvatinib (30 mg/kg) and the combined treatment (combo) group. b Response of lenvatinib-resistant PLC/PRF/5 xenografts to treatment with lenvatinib (30 mg/kg daily), palbociclib (100 mg/kg daily), or their combination through oral administration. Harvested tumors are shown. Scale bar = 1 cm. Five representative tumors in each group were shown. c Tumor growth curve showing the response towards each treatment (n = 5 mice in mock, lenvatinib and palbociclib while n = 6 mice for combo; two-tailed t test). d Waterfall plot showing the response of each tumor after 21 days (two-tailed Mann–Whitney U test). e Immunohistochemical images of β-catenin (n = 5) and PCNA (n = 4) in resected tumors (two-tailed t test). Scale bar = 5 µm. Protein signal intensity and number of positive nuclei was quantified using ImageJ software. Data was presented as mean ± standard deviation. Source data are provided as a Source Data file.