(A) Effort-related decision making was impaired in male, but not female, Gpr88Cre/Cre mice when effort was high (repeated-measures two-way analysis of variance with Geisser-Greenhouse correction and Tukey’s multiple comparisons test, schedule × group, F6,80 = 3.064, p = .0095, p < .05) (B) despite equal consumption of chow across all fixed ratio schedules (two-way repeated-measures analysis of variance, schedule × group, F6,80 = 0.9428, p = .4694). Individual data points presented with mean ± SEM; N = 10–12. FR, fixed ratio; WT, wild-type.