Table 3.

Associations Between Social Health Markers and Tract-Specific White Matter Integrity Stratified by Sex

	Sex	Association Tracts						Commissural Tracts		Limbic Tracts		Sensorimotor Tracts
Social Health Markers		ATR	IFO	ILF	PTR	SLF	UNC	FMA	FMI	CGC	CGH	FX	CST	MCP	ML	STR
Fractional Anisotropy
Social support, per point increase	Male	0.00	0.05	0.04	0.02	0.05a	0.03	0.00	0.06a	0.01	0.02	−0.02	0.00	−0.02	−0.01	0.03
Social support, per point increase	Female	0.00	0.00	0.01	0.03	0.02	0.01	0.02	0.03	0.01	0.02	0.01	0.02	−0.03	0.05a	0.00
Partner status, no partner vs. partner	Male	0.07	−0.12	−0.07	−0.07	−0.04	−0.05	−0.02	−0.22b,c	−0.09	−0.04	0.09	0.16a,c	0.04	0.12	0.11
Partner status, no partner vs. partner	Female	−0.03	−0.10a	−0.09	−0.10a	−0.03	−0.01	−0.04	−0.03	−0.05	−0.03	0.07	−0.05c	−0.03	−0.03	−0.06
Loneliness, lonely vs. not lonely	Male	−0.08	−0.01	0.03	−0.04	0.01	0.00	0.09	0.02	0.00	−0.06	−0.01	0.01	0.11	−0.11	0.07
Loneliness, lonely vs. not lonely	Female	−0.07	−0.09	−0.09	−0.10	−0.04	−0.09	−0.06	−0.05	−0.12	−0.07	−0.05	−0.01	−0.04	0.04	0.05
Mean Diffusivity
Social support, per point increase	Male	−0.02	−0.05a	−0.03	0.00	−0.05a	−0.05a	0.01	−0.07b,c	−0.04	−0.02	−0.02	−0.03a	−0.01	−0.02	−0.02
Social support, per point increase	Female	−0.03	−0.05a	−0.05a	−0.03	−0.03	−0.05a	−0.02	−0.05b	−0.03	0.00	−0.02	−0.02	0.03	−0.07	0.00
Partner status, no partner vs. partner	Male	0.07	0.15a	0.02	0.07	0.07	0.12	0.16a	0.08	0.12	0.13	0.04	0.07	0.04	0.01	0.03
Partner status, no partner vs. partner	Female	0.02	0.05	0.03	0.09a	0.06	0.03	0.03	0.02	0.10	0.11a	−0.01	0.11	0.04	0.04	0.14a
Loneliness, lonely vs. not lonely	Male	−0.02	0.04	−0.07c	0.00	0.06	0.04	0.02	0.05	0.00	0.14	−0.01	−0.03	0.16	0.01	−0.01c
Loneliness, lonely vs. not lonely	Female	0.03	0.09	0.11c	0.08	0.06	0.04	0.07	0.00	0.12	0.22a	−0.01	0.24a	0.02	−0.02	0.31b,c

Standardized mean differences of model 3 stratified by sex for fractional anisotropy and mean diffusivity.

ATR, anterior thalamic radiation, CGC, cingulate gyrus part of cingulum; CGH, parahippocampal part of cingulum; CST, corticospinal tract; FMA, forceps major; FMI, forceps minor; FX, fornix; IFO, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; MCP, middle cerebellar peduncle; ML, medial lemniscus; PTR, posterior thalamic radiation; SLF, superior longitudinal fasciculus; STR, superior thalamic radiation; UNC, uncinate fasciculus.

^aIndicates the statistically significant (p ≤ .05) coefficients without multiple testing correction.

^bIndicates the statistically significant coefficients after multiple testing correction (Šidák correction).

^cIndicates significant p values for the interaction term of the social health marker with sex.