Table 1.
Significant SNPs Identified From Genome-wide Analysis of REYD in Discovery and Replication Samples and Meta-analyses
|
CHR |
SNP | Pos | A1 | LD With rs75885813 | β |
SE |
Coefficient t-Statistic |
p |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Discovery | Replication | Discovery | Replication | Discovery | Replication | Discovery | Replication | Meta-analysis | |||||
| 16 | rs75885813 | 7,141,263 | T | – | −0.669 | −0.276 | 0.112 | 0.130 | −5.96 | −2.12 | 3.83 × 10−9 | 0.034 | 3.67 × 10−9 |
| 16 | rs114891671 | 7,142,203 | C | 0.98 | −0.669 | −0.352 | 0.113 | 0.135 | −5.90 | −2.60 | 5.56 × 10−9 | 0.0094 | 6.04 × 10−10 |
| 16 | rs115712598 | 7,142,236 | T | 0.98 | −0.669 | −0.352 | 0.113 | 0.135 | −5.90 | −2.60 | 5.56 × 10−9 | 0.0094 | 6.04 × 10−10 |
| 16 | rs116183707 | 7,142,287 | A | 0.98 | −0.669 | −0.352 | 0.113 | 0.135 | −5.90 | −2.60 | 5.56 × 10−9 | 0.0094 | 6.04 × 10−10 |
| 16 | rs7205995 | 7,140,331 | G | 0.98 | −0.667 | −0.35 | 0.113 | 0.135 | −5.88 | −2.59 | 6.05 × 10−9 | 0.0097 | 6.69 × 10−10 |
Five whole-genome–significant SNPs that are in high LD were identified (r2 > 0.8).
CHR, chromosome; LD, linkage disequilibrium; Pos, position; REYD, Rey Complex Figure Test Delayed Component; SNP, single nucleotide polymorphism.