Table 3.
Associations of CYP46A1 Gene Polymorphisms With the Susceptibility to MDD
| SNP | Allelea | HCb | MDDb | MAFc | Additive Modeld |
Dominant Modeld |
Recessive Modeld |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||||
| rs4905883 | G/T | 0/4/87 | 2/12/70 | 0.02/0.10 | 4.245 (1.39–12.96) | .011 | 4.500 (1.40–14.44) | .012 | NA | NA |
| rs1957512 | G/A | 1/7/83 | 2/17/65 | 0.05/0.13 | 2.542 (1.15–5.64) | .022 | 3.062 (1.26–7.46) | .014 | 2.222 (0.19–25.36) | .520 |
| rs1957513 | T/C | 1/7/83 | 2/16/66 | 0.05/0.12 | 2.387 (1.08–5.29) | .032 | 2.849 (1.16–6.98) | .022 | 2.222 (0.19–25.36) | .520 |
| rs1957515 | C/A, G, T | 1/8/82 | 2/18/64 | 0.05/0.13 | 2.439 (1.13–5.26) | .023 | 2.873 (1.22–6.75) | .015 | 2.222 (0.19–25.36) | .520 |
| rs6575744 | G/C | 1/7/83 | 2/16/66 | 0.05/0.12 | 2.387 (1.08–5.29) | .032 | 2.849 (1.16–6.98) | .022 | 2.222 (0.19–25.36) | .520 |
| rs35267715 | CA/C | 6/36/49 | 14/33/37 | 0.26/0.36 | 1.571 (0.99–2.48) | .052 | 1.489 (0.81–2.72) | .196 | 2.976 (1.06–8.36) | .038 |
HC, healthy control; MAF, minor allele frequency; MDD, major depressive disorder; NA, not available; OR, odds ratio; SNP, single nucleotide polymorphism.
a
Minor/major allele.
b
Rare homozygote/heterozygote/major homozygote.
c
HC subjects/patients with MDD.
d
Logistic regression with adjustment for age and sex.