Table 4.

Associations of the Changes in Oxysterol Levels and Improvement of Depressive Symptoms After Antidepressant Treatment

	HAMD-17		QIDS-SR16		PHQ-9
	t	p	t	p	t	p
24OHC
Baseline	1.092	.278	1.14	.269	0.974	.333
Week 2 – baseline	0.220	.826	0.497	.621	0.176	.861
Week 12 – baseline	−2.048	.045a	−1.733	.088	−0.899	.372
27OHC
Baseline	1.495	.139	1.699	.094	0.629	.531
Week 2 – baseline	0.030	.976	0.72	.474	0.843	.402
Week 12 – baseline	−2.432	.018a	−2.011	.048a	−0.365	.716
Cholesterol
Baseline	1.081	.283	1.071	.288	1.157	.251
Week 2 – baseline	0.175	.861	0.671	.449	0.748	.457
Week 12 – baseline	−0.641	.524	−0.435	.665	−0.652	.517

24OHC, 24(S)-hydroxycholesterol; 27OHC, 27-hydroxycholesterol; HAMD-17, 17-item Hamilton Depression Rating Scale; PHQ-9, Patient Health Questionnaire-9; QIDS-SR16, 16-item Quick Inventory of Depressive Symptoms–Self-Report.

^aStatistically significant differences.