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. 2023 Oct 23;13:18119. doi: 10.1038/s41598-023-43567-z

Figure 5.

Figure 5

Immunofluorescence microscopy of control, dehydrated, and cyclosporine-administrated renal tissue. Fluorescence microscopy of red/yellow-stained lysosomal-associated membrane protein 1 (LAMP 1) demonstrating the increase of perinuclear lysosomal staining in proximal tubules of cyclosporine-administrated animals (C) as compared to control (A) and dehydrated (B) animals. Blue represents Hoechst-stained nuclei, green is emitted renal tissue autofluorescence. Affected atrophic PTCs with an increased lysosomal load are marked within the yellow dotted line.