Table 2.
Results of Longitudinal Mediation Analyses of VRF Burden, Log CRP, and Single Depressive Symptoms
| Symptom | Total Effect (95% CI) | Direct Effect (95% CI) | Indirect Effect (95% CI) | Proportion Mediateda (95% CI) |
|---|---|---|---|---|
| Feelings of Depression | −0.002 (−0.012 to 0.008) | −0.002 (−0.012 to 0.008) | 0.000 (−0.001 to 0.001) | – |
| Inadequacy | −0.001 (−0.012 to 0.009) | −0.002 (−0.013 to 0.008) | 0.001 (−0.000 to 0.002) | – |
| Tiredness | 0.036 (0.021 to 0.051) | 0.033 (0.018 to 0.048) | 0.003 (0.002 to 0.005) | 9.6% (4.7% to 18.2%) |
| Lack of Interest | 0.002 (−0.009 to 0.012) | 0.001 (−0.009 to 0.011) | 0.001 (−0.000 to 0.001) | – |
| Changes in Appetite | 0.041 (0.030 to 0.052) | 0.039 (0.028 to 0.050) | 0.002 (0.001 to 0.004) | 5.5% (2.3% to 9.6%) |
| Thoughts of Suicide | 0.004 (−0.001 to 0.009) | 0.004 (−0.001 to 0.008) | 0.000 (−0.001 to 0.001) | – |
| Concentration Problems | 0.001 (−0.009 to 0.012) | 0.000 (−0.010 to 0.011) | 0.001 (−0.000 to 0.002) | – |
| Sleep Problems | 0.021 (0.003 to 0.039) | 0.020 (0.003 to 0.039) | 0.001 (−0.001 to 0.002) | – |
| Changes in Speed | −0.002 (−0.008 to 0.004) | −0.003 (−0.009 to 0.003) | 0.001 (−0.000 to 0.002) | – |
All associations are adjusted for covariates (age, gender, racial-ethnic background, educational attainment, household income, Townsend deprivation index, baseline depressive symptoms, potential history of mood disorder, and CRP at baseline).
CRP, C-reactive protein; VRF, vascular risk factor.
a
Proportion mediated was only calculated when total and indirect effects were significantly different from 0.