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. 2023 Jun 15;99(6):546–560. doi: 10.1016/j.jped.2023.05.005

Table 2.

Summary of the 15 articles found.

Reference Authors' names/Country Title Study Type Objective
14 Heiderich, T et al. (2015)/ Brasil Neonatal procedural pain can be assessed by computer software that has good sensitivity and specificity to detect facial movements. Software development for neonatal pain assessment. Develop and validate computer software to monitor neonatal facial movements of pain in real-time.
23 Carlini, L et al. (2021)/Brasil A Convolutional Neural Network-based Mobile Application to Bedside Neonatal Pain Assessment. A mobile application for smartphones for neonatal pain assessment. Propose and implement a mobile application for smartphones that uses Artificial Intelligence (AI) techniques to automatically identify the facial expression of pain in neonates, presenting feasibility in real clinical situations.
30 Grifantini, C (2020)/USA Detecting Faces, Saving Lives. Report: Discuss how facial recognition software is changing health care. Report on research using facial recognition technology, with machine learning algorithms and neural networks, and could be incorporated into hospitals to reduce pain and suffering and save lives.
30 cited 20 First citation in Grifantini, C (2020) Zamzmi, G et al. (2019)/USA Convolutional Neural Networks for Neonatal Pain Assessment Investigate the use of Convolutional Neural Networks for assessing neonatal pain. Investigate the use of a novel lightweight neonatal convolutional neural network as well as other popular convolutional neural network architectures for assessing neonatal pain.
30 cited 26 Second citation in Grifantini, C (2020) Zamzmi, G et al. (2022)/USA A Comprehensive and Context-Sensitive Neonatal Pain Assessment Using Computer Vision Present an automated system for neonatal pain assessment. Present a pain assessment system that utilizes facial expressions along with crying sounds, body movement, and vital sign changes.
31 Egede, J et al. (2019)/United Kingdom Automatic Neonatal Pain Estimation: An Acute Pain in Neonates Database. Present an automated system for neonatal pain assessment. Present a system for neonatal pain assessment which encodes pain indicative-features
32 Martinez-B, A et al. (2014)/Spain An Autonomous System to Assess, Display and Communicate the Pain Level in Newborns. Present an automated system for neonatal pain assessment - Web application. Present a system that automatically analyses the pain or discomfort levels of newborns.
33 Roué, J et al. (2021)/France Using sensor-fusion and machine-learning algorithms to assess acute pain in non-verbal infants: a study protocol. The study protocol, Clinical Trials, and Prospective observational study. Identify the specific signals and patterns from each facial sensor that correlate with the pain stimulus.
34 Cheng, X et al. (2022) /China Artificial Intelligence Based Pain Assessment Technology in Clinical Application of Real-World Neonatal Blood Sampling. Prospective study - The client-server model to run on the mobile. Analyze the consistency of the NPA results from a self-developed automated NPA system and nurses’ on-site NPAs (OS-NPAs).
35 Domingues, P et al. (2021)/Brasil Neonatal Face Mosaic: An areas-of-interest segmentation method based on 2D face images. Create a facial mosaic to aid in the facial assessment of neonatal pain. Propose the separation of the face into predefined polygonal regions relevant to pain detection in neonates.
36 Han, J et al. (2012)/Netherlands Neonatal Monitoring Based on Facial Expression Analysis. Development of a system to analyze various facial regions. Design a prototype of an automated video monitoring system for detecting discomfort in newborns by analyzing their facial expression.
37 Mansor, M et al. (2014)/Malaysia Infant Pain Detection with Homomorphic Filter and Fuzzy k-NN Classifier. Present an automated system for neonatal pain assessment. Evaluate the performance of illumination levels for infant pain classification.
38 Parodi, E et al. (2017)/Italy Automated Newborn Pain Assessment Framework Using Computer Vision Techniques. Proposed algorithm for neonatal pain assessment. Propose a computerized tool for neonatal pain evaluation based on patients’ facial expressions.
39 Wang, Y et al. (2022)/China Full‑convolution Siamese network algorithm under deep learning used in tracking of facial video image in newborns. Explore a new tracking network for neonatal pain assessment. Explore the full-convolution Siamese network in neonatal facial video image tracking application.
40 Dosso, Y et al. (2022)/Canada NICUface: Robust Neonatal Face Detection in Complex NICU Scenes Creation of robust NICU-face detectors. Create two neonatal face detection models (NICUface) by finetuning the most performant pre-trained face detection models on exceptionally challenging NICU scenes.

Note: AI, Artificial intelligence; Fuzzy k-NN, Fuzzy K-Nearest Neighbor; NICU, Neonatal Intensive Care Unit; NPA, Neonatal Pain Assessment; OS-NPAs, on-site NPAs.