TABLE 3.

EAT derived adipocytokines and cytokines.

Role	Factor	Major functions	References
Protective/anti‐inflammatory	Adiponectin	Anti‐inflammatory, antifibrotic, antiapoptotic, and antioxidative effects Cardiovascular protective effects Enhancing insulin sensitivity	205 , 206 , 207 , 209 , 211 , 214 , 216 , 217 , 218
	Omentin‐1	Anti‐inflammatory, antioxidative, antiapoptotic effects. Antiatherosclerosis and cardiovascular protective effects Suppressing insulin resistance	211 , 219 , 220
	IL‐10	Anti‐inflammatory effects	213 , 221 , 222
Pathologic/proinflammatory	Leptin	Regulating neuroendocrine function and energy homeostasis	207 , 208 , 214 , 215 , 216 , 223 , 224
	TNF‐α	Proinflammatory effects Inhibiting adiponectin secretion	41 , 213 , 225 , 226
	IL‐1		41 , 227
	IL‐6		209 , 228 , 229
	IL‐8		230
	Resistin	Proinflammatory effects Involved in insulin resistance, tumorigenesis	206 , 207 , 231 , 232 , 233