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. 2023 Oct 23;6(10):e2338995. doi: 10.1001/jamanetworkopen.2023.38995

Table 1. Participant Demographics.

Characteristic MyCode participants with p.Cys282Tyr homozygous results, No. (%) P value MyCode participants negative for p.Cys282Tyr homozygosity, (n = 86 300), No. (%) P value
MyCode identified (n = 144) Clinically identified (n = 57) Comparison to MyCode-identified participants Comparison to clinically identified participants
Age at medical record review, median (IQR) 56.6 (41.6-71.8) 65.7 (52.3-70.3) .07 62.0 (47.0-73.0) .045a .32
Sex assigned at birth
Female 85 (59.0) 29 (50.9) .29 52 994 (61.4) .55b .11b
Male 59 (41.0) 28 (49.1) 33 301 (38.6)
Unknown 0 0 5 (<0.1)
Ethnicityc
Not Hispanic or Latino 144 (100) 57 (100) NA 83 778 (97.1) .02a .42a
Unknown or Hispanic or Latino 0 0 2522 (2.9)
Racec
Black or African American 0 0 NA 1452 (1.7) .25b >.99b
White 144 (100) 57 (100) 84 189 (97.6)
Otherd 0 0 659 (0.8)
Alive at medical record review 138 (95.8) 53 (93.0) .47a 76 559 (88.7) .007a .31
Smoking status
Current 24 (16.7) 9 (15.8) >.99 14 086 (16.3) .35b .70b
Former 58 (40.3) 24 (42.1) 31 109 (36.0)
Never 61 (42.4) 24 (42.1) 40 825 (47.3)
Unknown 1 (0.7) 0 280 (0.3)
Active alcohol drinker
True 74 (51.4) 29 (50.9) >.99a 40 090 (46.4) .52b .81b
False 69 (47.9) 28 (49.1) 45 071 (52.2)
Not in medical record 1 (0.7) 0 1139 (1.3)
AUD 18 (12.5) 6 (10.5) .70 NA NA NA
Time from return of screening results, median (IQR), y 1.44 (1.35-1.51) NA NA NA NA NA
Length of EHR, median (IQR), y 22.2 (14.6-25.5) 21.3 (15.4-23.6) .72 17.0 (11.0-22.0) <.001a <.001a

Abbreviations: AUD, alcohol use disorder; EHR, electronic health record; NA, not applicable.

a

Calculated with Fisher exact test, with statistical significance at α = .05.

b

Calculated with Fisher exact test with Monte Carlo Estimation (seed = 1).

c

Race and ethnicity data were collected from the EHR.

d

Other included the following categories in the EHR: American Indian or Alaska Native (n = 109), Asian (n = 271), Native Hawaiian or Other Pacific Islander (n = 115), Other (n = 1), and Unknown (n = 163). The numbers for each category represent those of MyCode participants negative for p.Cys282Tyr homozygosity.