Table 1. Participant Demographics.
Characteristic | MyCode participants with p.Cys282Tyr homozygous results, No. (%) | P value | MyCode participants negative for p.Cys282Tyr homozygosity, (n = 86 300), No. (%) | P value | ||
---|---|---|---|---|---|---|
MyCode identified (n = 144) | Clinically identified (n = 57) | Comparison to MyCode-identified participants | Comparison to clinically identified participants | |||
Age at medical record review, median (IQR) | 56.6 (41.6-71.8) | 65.7 (52.3-70.3) | .07 | 62.0 (47.0-73.0) | .045a | .32 |
Sex assigned at birth | ||||||
Female | 85 (59.0) | 29 (50.9) | .29 | 52 994 (61.4) | .55b | .11b |
Male | 59 (41.0) | 28 (49.1) | 33 301 (38.6) | |||
Unknown | 0 | 0 | 5 (<0.1) | |||
Ethnicityc | ||||||
Not Hispanic or Latino | 144 (100) | 57 (100) | NA | 83 778 (97.1) | .02a | .42a |
Unknown or Hispanic or Latino | 0 | 0 | 2522 (2.9) | |||
Racec | ||||||
Black or African American | 0 | 0 | NA | 1452 (1.7) | .25b | >.99b |
White | 144 (100) | 57 (100) | 84 189 (97.6) | |||
Otherd | 0 | 0 | 659 (0.8) | |||
Alive at medical record review | 138 (95.8) | 53 (93.0) | .47a | 76 559 (88.7) | .007a | .31 |
Smoking status | ||||||
Current | 24 (16.7) | 9 (15.8) | >.99 | 14 086 (16.3) | .35b | .70b |
Former | 58 (40.3) | 24 (42.1) | 31 109 (36.0) | |||
Never | 61 (42.4) | 24 (42.1) | 40 825 (47.3) | |||
Unknown | 1 (0.7) | 0 | 280 (0.3) | |||
Active alcohol drinker | ||||||
True | 74 (51.4) | 29 (50.9) | >.99a | 40 090 (46.4) | .52b | .81b |
False | 69 (47.9) | 28 (49.1) | 45 071 (52.2) | |||
Not in medical record | 1 (0.7) | 0 | 1139 (1.3) | |||
AUD | 18 (12.5) | 6 (10.5) | .70 | NA | NA | NA |
Time from return of screening results, median (IQR), y | 1.44 (1.35-1.51) | NA | NA | NA | NA | NA |
Length of EHR, median (IQR), y | 22.2 (14.6-25.5) | 21.3 (15.4-23.6) | .72 | 17.0 (11.0-22.0) | <.001a | <.001a |
Abbreviations: AUD, alcohol use disorder; EHR, electronic health record; NA, not applicable.
Calculated with Fisher exact test, with statistical significance at α = .05.
Calculated with Fisher exact test with Monte Carlo Estimation (seed = 1).
Race and ethnicity data were collected from the EHR.
Other included the following categories in the EHR: American Indian or Alaska Native (n = 109), Asian (n = 271), Native Hawaiian or Other Pacific Islander (n = 115), Other (n = 1), and Unknown (n = 163). The numbers for each category represent those of MyCode participants negative for p.Cys282Tyr homozygosity.