A, Among living patients with frailty at 6 months, 40% still received chemotherapy, and 60% either completed or discontinued treatment. Among living patients with frailty at 12 months, 17% still received chemotherapy, and 83% either completed or discontinued treatment. B, Among living patients without frailty at 6 months, 30% still received chemotherapy, and 70% either completed or discontinued chemotherapy. Among living patients without frailty at 12 months, 9% still received chemotherapy, and 91% completed or discontinued treatment. C and D, Frailty domains include somatic, functional, psychological, and social. Decline represents either a decline in quality of life (QOL) or a decline in physical functioning (PF). No follow-up consists of living patients without a completed follow-up questionnaire at the specified time point.