Table 2. Association Between Grade 3 or Higher Toxic Effects and Unfavorable Outcomes at 6 Months and 12 Months^a.

Grade ≥3 toxic effects by time since initiation of chemotherapy	Univariable logistic regression		Multivariable logistic regressionb
	Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
All patients
6 mo	1.42 (0.83-2.42)	.20	1.47 (0.85-2.55)	.17
12 mo	1.08 (0.62-1.90)	.78	1.08 (0.60-1.94)	.80
Patients with frailty
6 mo	2.41 (1.07-5.41)	.03	2.62 (1.14-6.05)	.02
12 mo	1.00 (0.42-2.37)	1.00	1.09 (0.45-2.64)	.86
Patients without frailty
6 mo	0.79 (0.38-1.65)	.54	0.76 (0.36-1.64)	.49
12 mo	1.05 (0.48-2.27)	.91	1.06 (0.46-2.43)	.90

^a Unfavorable outcomes include decline in quality of life and/or physical functioning or mortality.

^b Multivariable logistic regression models were adjusted for age, hospital type, and treatment intent. Toxic effects, treatment intent, and hospital were added to the model as binary variables and age was added as a continuous variable.