Figure 5.
Overview of some of the numerous bispecific design strategies for bispecific antibodies. The heavy chains are colored bright pink/blue, the light chains are depicted in light blue/pink and gray. The upper row shows Fv formats focusing on engineering and optimizing the VH-VL interface on the left, as well as heavy chain heterodimerization approaches (CH3-CH3 complementarity), whereas the lower row represents the light chain heterodimerization strategies concerning mainly the CH1-CL interface.