Ikuta 2004 (A).

Study characteristics
Methods	Randomised controlled trial Run‐in period: April 2001‐February 2002 Published 2004 Number of centres and location: not specified
Participants	Twenty‐three participants were assessed in part A of this study. Inclusion criteria: first‐time elective CABG Exclusion criteria: previous cardiac surgery, renal or liver dysfunction, and preoperative coagulopathy
Interventions	Intervention: Heparin‐coated CPB circuit Control: Uncoated circuit.
Outcomes	Plt preservation by number of Plts C activation by C3a and C4a levels Inflammatory response by IL‐6 and IL‐8 levels
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Forty‐five patients undergoing CABG were randomly assigned to PMEA‐coated (group P, n = 15), heparin‐coated (group H, n = 15), and noncoated (group N, n = 15) circuit groups.
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details given
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details given
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data included in analysis
Selective reporting (reporting bias)	Low risk	No reporting bias apparent
Other bias	Unclear risk	Not clearly stated