Immer 2007.

Study characteristics
Methods	Randomised substudy – cohort of larger patients Run‐in period: not specified. Accepted for publication May 29, 2007 Number of centres and location: University Hospital, Berne, Switzerland
Participants	A total of 1053 patients were assessed in this study; 60 participants were randomised to MiECC or CCPB circuit. Inclusion criteria: patients undergoing CABG Exclusion criteria: re‐do CABG and combined CABG operations (with valve surgery, aortic surgery, or both)
Interventions	Intervention: MiECC Control: CCPB
Outcomes	cTnI, CK‐MB, IL‐6, SC5b‐9, human lactoferrin (HL)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details given
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details given
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details given
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data included in analysis
Selective reporting (reporting bias)	Low risk	No reporting bias apparent
Other bias	Unclear risk	No details given