Inui 1999.

Study characteristics
Methods	Randomised controlled trial Run‐in period: not specified. Received November 1998; revised February 1999. Published 1999 Number of study centres and location: not specified
Participants	Twenty‐four participants were assessed in this study. Inclusion criteria: adult patients undergoing cardiac surgery
Interventions	Intervention: Duraflo II heparin‐coated CPB circuits Control: uncoated circuit
Outcomes	TNF‐α, IL‐6, IL‐8, MPO, TAT, PIC, TM
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Twenty‐four patients were randomly assigned to be investigated. Nine participants underwent CABG, and 15 underwent valve replacement or valve repair surgery.
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details given
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details given
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data included in analysis
Selective reporting (reporting bias)	Low risk	No reporting bias apparent
Other bias	Unclear risk	No details given