Kiessling 2018.

Study characteristics
Methods	Randomised controlled trial: Run‐in period: March‐June 2016 Number of study centres and location: single centre. Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
Participants	A total of 72 participants were assessed in this study. Inclusion criteria: planned CABG procedures with ECC support and age > 64 years Exclusion criteria: CABG procedures in combination with operations on the carotid arteries, aorta, or valves. Patients who underwent a reoperation, had an AMI (ST‐elevation MI or non‐ST‐elevation MI < 7 days ago), had elevated serum Cr levels (> 1.8 mg/dL), had elevated liver enzymes (AST, ALT > 2× above norm), or had decreased Hb (Hb < 11 mg/dL) were also excluded.
Interventions	Intervention: MiECC system Control: standard CPB
Outcomes	Renal function, inflammatory response, ischaemia, coagulation, and haemolysis and clinical data
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details given
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unblinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unblinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data included in analysis
Selective reporting (reporting bias)	Low risk	No reporting bias apparent
Other bias	Unclear risk	No details given